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Strong Recommendation for Pyronaridine-Artesunate in Revised World Health Organization (WHO) Malaria Treatment Guidelines

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Malaria

Inclusion in the latest version of the WHO Guidelines for malaria is a key step towards broader use of the medicine

GENEVA, Switzerland, November 25, 2022/APO Group/ — 

MMV (http://www.MMV.org) and Shin Poong Pharm. Co., Ltd. welcome the formal inclusion of Pyramax® (pyronaridine-artesunate) in the World Health Organization’s (WHO) Guidelines for Malaria (http://bit.ly/3EZSJep) following an extensive review process.

The WHO’s Guidelines for the Treatment of Malaria are the standard reference which guide country-level policies for managing malaria. New medicines are only recommended for inclusion following a robust and in-depth evaluation of evidence using the GRADE (http://bit.ly/3XuGnSy) framework, which provides a systematic approach for making clinical practice recommendations. Following this review – which included one of the largest clinical studies to evaluate real-world efficacy and safety of any antimalarial – the Guideline Development Committee recommended the formal inclusion of Pyramax in the guidelines with a “STRONG” recommendation – the highest level of confidence.

Pyramax is a fixed dose artemisinin-based combination therapy (ACT) and the only one to be specifically indicated for the blood-stage treatment of the two dominant species of malaria parasite: P. falciparum and P. vivax. The medicine is also available in a child-friendly granule formulation to ensure palatability and therefore correct dosage in this vulnerable population.

Both Pyramax tablets and Pyramax granules received European Medicines Agency (EMA) positive scientific opinions from the Committee for Medicinal Products for Human Use (CHMP) through Article 58, based on a robust development programme.  To date, over 2.9 million malaria patients have been treated with the medicine, including children under the age of 1.

Both formulations are currently registered for the treatment of uncomplicated malaria in 29 countries in Africa and Asia.  

Following the positive scientific opinions for use, a large Cohort Event Monitoring study was implemented in 5 African countries [1] under the supervision of the CANTAM Network [2] to evaluate the safety and effectiveness of Pyramax under conditions similar to everyday clinical practice. This study, which reported high effectiveness (D28 PCR-adjusted cure rate of 98.6%), included over 8,500 acute malaria episodes in 7,154 patients, and has recently been published in PLoS Medicine [3].

Pyramax was included in the WHO’s list of pre-qualified medicines in 2012, and in the WHO’s Essential Medicines Lists for both adults and children in 2017. Pyramax has subsequently undergone a positive review by the WHO’s Advisory Committee on the Safety of Medicinal Products in 2019, which included a review of interim data from the CANTAM study.

The addition of Pyramax to the WHO Guidelines for malaria is an achievement that we are proud to have reached with our long-standing partner Shin Poong Pharm. Co., Ltd.

Following this review in October 2019 and pending the next revision of their Guidelines for Malaria, the WHO published an Information Note supporting the use of Pyramax at country level, stating that “artesunate-pyronaridine can be considered a safe and efficacious ACT for the treatment of uncomplicated malaria in adults and children weighing 5 kg and over in all malaria-endemic areas….countries can consider including this medicine in their national treatment guidelines for the treatment of malaria”.

“The addition of Pyramax to the WHO Guidelines for malaria is an achievement that we are proud to have reached with our long-standing partner Shin Poong Pharm. Co., Ltd.,” said Dr David Reddy, MMV’s CEO. “We ventured into the Pyramax project to help save the lives of adults and children with malaria. Therefore, we will continue to work with Shin Poong to register both the tablets and granules of Pyramax in more malaria-endemic countries, facilitating equitable access to this important new addition to the malaria treatment toolkit.”
 

“The official inclusion of Pyramax into WHO’s Guidelines for malaria is a crucial step allowing malaria endemic countries to choose Pyramax as a first line ACT with confidence. The managerial decision to commence the Pyramax project was based on Shin Poong’s core values and company policies, which have guided us for over half a century. We will continue to produce qualified products to supply potent, reliable, simple treatment to patients”, said Shin Poong Pharm. Co., Ltd.


[1] Gabon: Albert Schweitzer Hospital (CERMEL), Lambaréné, Côte d’Ivoire: Health Center of Azaguié & Health Center of Agboville, Cameroon: Biotechnology Center, University of Yaoundé & Mfou District Hospital, Congo: Congo foundation for the Medical Research, Brazzaville, Makélélé Hospital, Health Center of Madibou, DR of Congo: Faculty of Medicine, University of Kinshasa, Mont-Amba Hospital, Kinshasa, Evangelic Medical Institute of Kimpesé 

[2] For more information about CANTAM, please visit: http://bit.ly/3GGf9CE

[3] To read the CANTAM study, please visit: http://bit.ly/3u4n6tD

Distributed by APO Group on behalf of Medicines for Malaria Venture.

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International Islamic Trade Finance Corporation (ITFC) Engages Stakeholders During the World Trade Organization Aid for Trade Review 2024 Event

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ITFC

African Finance Corporation, International Trade Centre, ITFC, WTO, Afreximbank, and UNIDO Sign Joint Declaration to Promote Cooperation in Support of the Cotton Sector

JEDDAH, Saudi Arabia, July 4, 2024/APO Group/ — 

The International Islamic Trade Finance Corporation (ITFC) (www.ITFC-idb.org), a member of the Islamic Development Bank (IsDB) Group is pleased to announce the Corporation’s active participation at the 9th World Global Review for Trade. This event, themed ‘Mainstreaming Trade’, was held at the World Trade Organization’s (WTO) headquarters, in Geneva from June 26 to 28, 2024.

The World Trade Organization (WTO) Aid for Trade Review is a significant global platform that brings together policymakers, development agencies, and trade experts to discuss strategies and initiatives to promote trade as a means of development. This year’s theme highlighted the importance of integrating trade into national development strategies for sustainable economic growth.

ITFC remains committed to strengthening existing partnerships and leveraging new synergies to provide our member countries with trade solutions best suited to global dynamics

The event was an occasion for ITFC to cement its strategic partnerships with the international trade community, explore new areas of cooperation, and present IsDB Group’s achievement with the publication of the IsDB Aid for Trade Report.

A joint declaration was signed between Eng. Hani Salem Sonbol, CEO of ITFC; H.E. Ngozi Okonjo-Iweala, Director General of the WTO, Benedict Oramah, President and Chairman of the Board of the African Export-Import Bank (Afreximbank); Gerd Müller, Director General of UNIDO; Samaila Zubairu, President and CEO of the Africa Finance Corporation (AFC), and Pamela Coke-Hamilton, Executive Director of the International Trade Centre (ITC).  The joint declaration will strengthen cooperation in areas of common interest under the coalition ‘Partenariat pour le coton’ by establishing sustainable textile hubs, supporting private sector investments, and encouraging collaboration and advocacy in Africa and beyond.

 The signature ceremony was followed by a high-level panel session titled “Cotton to Clothing: Charting Pathways to Create Sustainable Jobs for Women and Youth in West and Central Africa”. Mr. Sonbol underscored the long-lasting involvement of ITFC in cotton production in the past 15 years: US$2 billion financed to connect firms and millions of smallholders’ cotton farmers to global value chains. He also presented ITFC’s solutions programs as solutions to support investment promotion, market access, and capacity building to enable the environment for a regional textile value chain in Africa.  

In addition, Eng. Hani Salem Sonbol participated in a panel session on “Financing Aid for Trade—Regional Perspectives,” highlighting the potential for economic transformation of OIC member countries through regional integration and showcasing IsDB Group synergy that allows to offer robust regional programs to OIC member countries in different continents. 

Commenting on ITFC’s participation during the WTO Aid for Trade Review 2024, Eng. Hani Salem Sonbol, ITFC CEO, said: “ITFC’s participation at the 9th World Global Review for Trade is a clear testament to our good relations with the World Trade Organization and our support for their mission of leveraging trade to generate employment opportunities and improve livelihoods. ITFC remains committed to strengthening existing partnerships and leveraging new synergies to provide our member countries with trade solutions best suited to global dynamics. We look forward to further supporting sustainable trade, trade finance, and value creation through these strategic partnerships.”

Distributed by APO Group on behalf of International Islamic Trade Finance Corporation (ITFC).

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Republic of Congo Hydrocarbons Minister to Discuss Gas Monetization at Angola Oil & Gas (AOG) 2024

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Hydrocarbons

Both the Republic of Congo and Angola have outlined ambitious oil and gas production targets, representing strategic areas for bilateral investment and cooperation

LUANDA, Angola, July 4, 2024/APO Group/ — 

Bruno Jean-Richard Itoua, Minister of Hydrocarbons of the Republic of Congo (ROC), has joined the Angola Oil & Gas (AOG) conference as a speaker. During the conference – scheduled for October 2-3 in Luanda – Minister Itoua will provide insight into emerging opportunities in oil exploration, gas monetization and LNG development, as well as potential areas for collaboration between the two countries.

Both ROC and Angola have set bold production targets, aiming to increase oil output to 500,000 barrels per day (bpd) and 1.1 million bpd, respectively. Both countries’ favorable investment climates have sparked the interest of a strong slate of E&P firms, with AOG 2024 set to not only support national oil and gas objectives, but also offer a platform for engagement in emerging cross-border projects.  

AOG is the largest oil and gas event in Angola. Taking place with the full support of the Ministry of Mineral Resources, Oil and Gas; national oil company Sonangol; the National Oil, Gas and Biofuels Agency; the African Energy Chamber; and the Petroleum Derivatives Regulatory Institute, the event is a platform to sign deals and advance Angola’s oil and gas industry. To sponsor or participate as a delegate, please contact sales@energycapitalpower.com.

To support oil production, ROC is promoting investment in frontier exploration alongside incremental production from existing assets. The Central African country – with 1.8 billion barrels of proven oil reserves – has several upstream campaigns underway that aim to unlock new discoveries. Independent energy company Perenco, for example, completed 3D seismic surveys at the Tchibouela II, Tchendo II, Marine XXVIII and Emeraude permits in November 2023. Energy major TotalEnergies has announced plans to invest $600 million to drive exploration and production activities in the country, specifically through the development of the Moho Nord field. The field currently accounts for nearly half of total Congolese oil production, producing an estimated 140,000 bpd. The investment will support drilling operations in line with national targets to bolster output.

Meanwhile, ROC is committed to monetizing its gas resources through both associated and non-associated projects. The country reached a milestone in March 2024 with the delivery of its first LNG cargo to Italy from the Congo LNG development. As the country’s inaugural LNG facility, the project employed a fast-tracked approach whereby LNG was produced just 12 months after FID. By 2025, the Congo LNG project is expected to produce 2.4 million tons per annum, with ROC joining the likes of Angola as a major African LNG exporter.

Further supporting its gas monetization drive, ROC is making progress with the development of the Bango Kayo project. Set to reach peak oil production of 50,000 bpd, project developer Wing Wah is deploying an integrated approach to expand the project through multiple phases. The project will begin monetizing previously-flared gas to support the country’s industrial sector, serving as a model for other African oil producers including Angola, which is striving to maximize production from mature assets.

Minister Itoua’s participation at AOG 2024 not only speaks to the caliber of the event as the premier oil and gas conference in Angola, but creates new opportunities for bilateral collaboration in the fields of LNG production and oilfield development. Angola and ROC – both offering promising opportunities in offshore exploration and tie-ins to existing onshore infrastructure – represent highly attractive hydrocarbons markets, with the AOG 2024 conference set to connect global investors with prospective opportunities.

Minister Itoua will be joined by Maixent Raoul Ominga, Managing Director of the Congo’s national oil company Société Nationale des Pétroles du Congo at AOG 2024. For more information, visit www.AngolaOilAndGas.com.

Distributed by APO Group on behalf of Energy Capital & Power.

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Gazprom Joins African Energy Week (AEW) 2024 as Silver Sponsor, Driving Africa’s Gas Momentum

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Gazprom

Russian multinational energy corporation Gazprom will join African Energy Week: Invest in African Energy 2024, affirming its commitment to advancing sustainable and gas-focused energy solutions across the continent

CAPE TOWN, South Africa, July 4, 2024/APO Group/ — 

Russian multinational energy corporation Gazprom is spearheading a crucial refinery upgrade project at the Mossel Bay gas-to-fuel facility in South Africa – which advanced to feasibility stage last month – as part of efforts to support Africa’s gas monetization agenda and secure a reliable supply of refined petroleum products. As the world’s largest producer of natural gas, Gazprom will join African Energy Week (AEW): Invest in African Energy – taking place in Cape Town on November 4-8 – as a Silver Sponsor, bringing valuable insights and perspectives on harnessing Africa’s substantial gas resources.

For Africa, natural gas represents the key to achieving broad energy security and diversified economic growth. With over 620 trillion cubic feet (tcf) of proven gas reserves, the continent is seeking to ramp up gas exploration efforts, while establishing integrated, gas-based networks and downstream industries. Through new exploration campaigns, Nigeria is aiming to expand its gas reserves from 200 tcf to 600 tcf; Mozambique is spearheading development of the 18-million-ton-per-year (mtpa) Rovuma LNG and 13-mtpa Mozambique LNG facilities; and Algeria is driving production through a gas-boosting project at the Hassi R’Mel gas field. The 2.3-mtpa Greater Tortue Ahmeyim LNG project in Senegal and Mauritania anticipates first production later this year, while the Tanzania LNG project is set to produce 10 million mtpa once approval by the government is secured.

AEW: Invest in African Energy stands as the premier platform for project operators, financiers, technology providers, and governments, recognized as the definitive venue for sealing deals in African energy. For more information about this pivotal event, visit www.AECWeek.com.

Gazprom is consistently expanding its dialogue with African countries and stands ready to share its unique know-how and best practices

Gazprom’s expertise in gas exploration, production, processing and export positions it as a viable partner to Africa’s natural gas agenda. Last year, the company partnered with the African Energy Chamber (AEC) to host the International Gas Roundtable, an exclusive event highlighting the pivotal role of gas in stimulating economic development across the continent. The roundtable served as a unique platform to explore innovative strategies, exchange best practices and shape the future of gas development, providing valuable insights for both mature and emerging African gas producers.  

“Gazprom is consistently expanding its dialogue with African countries and stands ready to share its unique know-how and best practices in realizing mutually profitable energy industry projects with potential partners from Africa. Gazprom possesses all the necessary technologies and innovations capable to assist African countries in securing energy industry development based on the existing natural gas reserves, in decreasing the level of ‘energy poverty,’ and in improving the quality of life of the populations of African countries, as well as in resolving environmental problems,” states Dmitry Khandoga, Head of International Business at Gazprom.

Gazprom’s technical expertise in the gas sector demonstrates the potential for Africa to increase production and unlock new export markets. With projects like the Nigeria-Morocco Gas Pipeline and Trans-Saharan Gas Pipeline set to supply African gas to regional and European markets, Gazprom’s expertise is particularly crucial, as it operates a number of pipelines that deliver gas across the country and transnationally. The company deploys cutting-edge technologies in the design and maintenance of pipelines, such as the application of corrosion-resistant materials and automated monitoring systems, which increase the reliability and durability of gas infrastructure. At AEW: Invest in African Energy, Gazprom will share its expertise to foster collaboration with industry leaders, advocate for sustainable energy practices and forge partnerships that work towards Africa’s energy security and growth.

“Natural gas is a strategic tool in the fight against energy poverty in Africa. It represents a reliable, scalable and cost-effective solution for power generation and industrial growth. Gazprom’s technical expertise across the entire gas value chain – which makes it the world’s largest gas producer – provides a valuable blueprint for African nations looking to harness gas for domestic use and export,” states NJ Ayuk, Executive Chairman of the AEC.

Returning to this year’s edition of AEW: Invest in African Energy, Gazprom will bring a wealth of expertise in the exploration, production, transportation, storage, processing, and sales of gas, gas condensate and oil. By collaborating with industry leaders and African stakeholders, Gazprom aims to support the continent’s journey towards energy independence and sustainable development.

Distributed by APO Group on behalf of African Energy Chamber.

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