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Strong Recommendation for Pyronaridine-Artesunate in Revised World Health Organization (WHO) Malaria Treatment Guidelines

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Malaria

Inclusion in the latest version of the WHO Guidelines for malaria is a key step towards broader use of the medicine

GENEVA, Switzerland, November 25, 2022/APO Group/ — 

MMV (http://www.MMV.org) and Shin Poong Pharm. Co., Ltd. welcome the formal inclusion of Pyramax® (pyronaridine-artesunate) in the World Health Organization’s (WHO) Guidelines for Malaria (http://bit.ly/3EZSJep) following an extensive review process.

The WHO’s Guidelines for the Treatment of Malaria are the standard reference which guide country-level policies for managing malaria. New medicines are only recommended for inclusion following a robust and in-depth evaluation of evidence using the GRADE (http://bit.ly/3XuGnSy) framework, which provides a systematic approach for making clinical practice recommendations. Following this review – which included one of the largest clinical studies to evaluate real-world efficacy and safety of any antimalarial – the Guideline Development Committee recommended the formal inclusion of Pyramax in the guidelines with a “STRONG” recommendation – the highest level of confidence.

Pyramax is a fixed dose artemisinin-based combination therapy (ACT) and the only one to be specifically indicated for the blood-stage treatment of the two dominant species of malaria parasite: P. falciparum and P. vivax. The medicine is also available in a child-friendly granule formulation to ensure palatability and therefore correct dosage in this vulnerable population.

Both Pyramax tablets and Pyramax granules received European Medicines Agency (EMA) positive scientific opinions from the Committee for Medicinal Products for Human Use (CHMP) through Article 58, based on a robust development programme.  To date, over 2.9 million malaria patients have been treated with the medicine, including children under the age of 1.

Both formulations are currently registered for the treatment of uncomplicated malaria in 29 countries in Africa and Asia.  

Following the positive scientific opinions for use, a large Cohort Event Monitoring study was implemented in 5 African countries [1] under the supervision of the CANTAM Network [2] to evaluate the safety and effectiveness of Pyramax under conditions similar to everyday clinical practice. This study, which reported high effectiveness (D28 PCR-adjusted cure rate of 98.6%), included over 8,500 acute malaria episodes in 7,154 patients, and has recently been published in PLoS Medicine [3].

Pyramax was included in the WHO’s list of pre-qualified medicines in 2012, and in the WHO’s Essential Medicines Lists for both adults and children in 2017. Pyramax has subsequently undergone a positive review by the WHO’s Advisory Committee on the Safety of Medicinal Products in 2019, which included a review of interim data from the CANTAM study.

The addition of Pyramax to the WHO Guidelines for malaria is an achievement that we are proud to have reached with our long-standing partner Shin Poong Pharm. Co., Ltd.

Following this review in October 2019 and pending the next revision of their Guidelines for Malaria, the WHO published an Information Note supporting the use of Pyramax at country level, stating that “artesunate-pyronaridine can be considered a safe and efficacious ACT for the treatment of uncomplicated malaria in adults and children weighing 5 kg and over in all malaria-endemic areas….countries can consider including this medicine in their national treatment guidelines for the treatment of malaria”.

“The addition of Pyramax to the WHO Guidelines for malaria is an achievement that we are proud to have reached with our long-standing partner Shin Poong Pharm. Co., Ltd.,” said Dr David Reddy, MMV’s CEO. “We ventured into the Pyramax project to help save the lives of adults and children with malaria. Therefore, we will continue to work with Shin Poong to register both the tablets and granules of Pyramax in more malaria-endemic countries, facilitating equitable access to this important new addition to the malaria treatment toolkit.”
 

“The official inclusion of Pyramax into WHO’s Guidelines for malaria is a crucial step allowing malaria endemic countries to choose Pyramax as a first line ACT with confidence. The managerial decision to commence the Pyramax project was based on Shin Poong’s core values and company policies, which have guided us for over half a century. We will continue to produce qualified products to supply potent, reliable, simple treatment to patients”, said Shin Poong Pharm. Co., Ltd.


[1] Gabon: Albert Schweitzer Hospital (CERMEL), Lambaréné, Côte d’Ivoire: Health Center of Azaguié & Health Center of Agboville, Cameroon: Biotechnology Center, University of Yaoundé & Mfou District Hospital, Congo: Congo foundation for the Medical Research, Brazzaville, Makélélé Hospital, Health Center of Madibou, DR of Congo: Faculty of Medicine, University of Kinshasa, Mont-Amba Hospital, Kinshasa, Evangelic Medical Institute of Kimpesé 

[2] For more information about CANTAM, please visit: http://bit.ly/3GGf9CE

[3] To read the CANTAM study, please visit: http://bit.ly/3u4n6tD

Distributed by APO Group on behalf of Medicines for Malaria Venture.

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TAAG Angola Airlines Takes Delivery of its First Boeing 787 Dreamliner

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TAAG Angola Airlines

The 787-9 and subsequent deliveries of the fuel-efficient widebody jet will advance the airline’s fleet modernization plans and long-haul capabilities, bringing more travelers and trade to Angol

LUANDA, Angola, January 31, 2025/APO Group/ —

  • African airline receives first of four 787 Dreamliner airplanes on order
  • 787 Dreamliner to expand TAAG Angola Airlines’ network in Europe and open new opportunities in Asia and North America

Boeing [NYSE: BA] (www.Boeing.com) delivered the first of four 787 Dreamliner airplanes to TAAG Angola Airlines, debuting the airline’s new livery. The 787-9 and subsequent deliveries of the fuel-efficient widebody jet will advance the airline’s fleet modernization plans and long-haul capabilities, bringing more travelers and trade to Angola with the industry’s most advanced commercial airplane.

The airline’s first 787 Dreamliner, which is on lease from AerCap, arrived in Luanda just ahead of Angola’s Liberation Day on February 4, marking nearly 50 years since the delivery of TAAG Angola’s first airplane, a Boeing 737-200.

“The delivery of the 787-9 is a pivotal step in our strategy to modernize TAAG Angola Airlines’ fleet,” said Nelson Pedro Rodrigues de Oliveira, CEO of TAAG Angola Airlines. “This airplane brings the efficiency and versatility we need to meet growing market demands, replace our aging widebody fleet, and deliver a world-class experience to our passengers.”

This airplane brings the efficiency and versatility we need to meet growing market demands, replace our aging widebody fleet, and deliver a world-class experience to our passengers

TAAG Angola Airlines currently operates five 777-300ER (Extended Range) airplanes, three 777-200ERs, and seven Next-Generation 737s, connecting Angola to 12 destinations across Africa, Europe, South America and China. The introduction of the 787 Dreamliner will enable the carrier to expand its long-haul network, with plans to launch new routes to Europe and explore opportunities in Asia and North America.

“The 787 Dreamliner will complement TAAG Angola Airlines’ fleet of Boeing 737 and 777 jets, as we continue to support the airline in its mission to connect people and places across the globe,” said Anbessie Yitbarek, vice president of Boeing Commercial Sales for Africa. “Our 50-year relationship with TAAG Angola Airlines has been built on trust and shared goals, and we look forward to many more years of successful collaboration and innovation together.”

The 787 Dreamliner, which TAAG Angola Airlines ordered in 2023 (https://apo-opa.co/4hEsiLC), is a core part of the operator’s modernization efforts. Recognized for its advanced technologies, fuel efficiency, and exceptional passenger experience, the 787 Dreamliner reduces fuel consumption and CO2 emissions by up to 25% compared to the airplanes it will replace.

Coinciding with the delivery of TAAG Angola Airlines’ first 787 Dreamliner, the airline is working with Boeing to purchase CO2 emissions reduction associated with blended Sustainable Aviation Fuel (SAF) through an accounting process called book-and-claim. Distributors will deliver the blended SAF made available through these purchased certificates to nearby airports for use by airlines and other carriers.

Boeing’s Commercial Market Outlook projects Africa will need 1,170 airplanes over the next two decades. Boeing airplanes have formed the backbone of Africa’s commercial fleet for over 75 years. More than 60 airlines operate around 500 Boeing airplanes throughout Africa, which represents nearly 70% of the airplane market across the continent.

Distributed by APO Group on behalf of Boeing.

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Forging Sustainable Partnerships in Africa’s Mining Sector: A High-Level Reception for Global Industry Leaders

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Mining

Key areas of focus will include the role of policy stability in driving investor confidence, the impact of ESG compliance on financing and operations, and the growing importance of local beneficiation and value addition

CAPE TOWN, South Africa, January 31, 2025/APO Group/ — 

As Africa’s mining industry navigates an era of transformation, CLG (www.CLGGlobal.com) will host an exclusive gathering of global investors, government representatives, legal experts, and energy industry leaders on Wednesday, 5 February 2025, to explore pathways for sustainable partnerships that drive long-term value creation.

Under the theme “African Mining Investors and Government: Forging Sustainable Partnerships,” the reception will serve as a premier platform for dialogue on the evolving regulatory environment, investment climate, and critical policy frameworks shaping the future of mining in Africa. With the continent’s vast mineral wealth presenting unparalleled opportunities, the ability to strike a balance between investment attractiveness, sustainability, and equitable resource governance remains at the forefront of industry discussions.

Key areas of focus will include the role of policy stability in driving investor confidence, the impact of ESG compliance on financing and operations, and the growing importance of local beneficiation and value addition. As governments refine their regulatory approaches to enhance sector transparency and long-term growth, legal expertise plays an increasingly vital role in ensuring that agreements, policies, and partnerships are structured for resilience and mutual benefit.

With global demand for critical minerals on the rise, Africa’s ability to position itself as a reliable and competitive supplier will depend on well-structured partnerships between public and private sector stakeholders. The event will highlight innovative approaches to cross-border collaboration, risk mitigation in mining investments, and strategies for ensuring resource nationalism policies align with sustainable economic development.

At CLG, we are committed to shaping the conversations that drive responsible and transformative mining investments on the continent

Bringing together high-profile decision-makers from across the global mining value chain, this reception will provide unparalleled networking opportunities, facilitating meaningful engagement on how best to harness Africa’s mineral wealth for long-term prosperity.

Zion Adeoye, Chief Executive Officer at CLG, emphasized the importance of robust legal frameworks in fostering investor confidence and ensuring mutually beneficial partnerships.

“Africa’s mining sector is entering a crucial phase where collaboration between investors and governments must be guided by well-defined legal and policy structures. Sustainable resource development requires not just capital investment, but strategic alignment between regulatory certainty, environmental stewardship, and local economic growth. At CLG, we are committed to shaping the conversations that drive responsible and transformative mining investments on the continent.”

Oneyka Cindy Ojogbo, a Partner at CLG, underscored the firm’s commitment to bridging the gap between legal innovation and industry growth.

“As the mining industry evolves, the need for strategic legal and regulatory guidance has never been greater. Investors and governments alike must adopt proactive legal frameworks that not only mitigate risk but also foster innovation and long-term sustainability. CLG is at the forefront of these discussions, ensuring that mining agreements, policies, and partnerships are structured to create lasting value for all stakeholders.”

Hosted by CLG, this reception underscores the firm’s leadership in navigating the legal, financial, and regulatory complexities of Africa’s mining sector. As a trusted advisor to investors, governments, and industry stakeholders, CLG remains committed to fostering strategic conversations that drive sustainable development and long-term economic success in the industry.

To be part of this high-level Reception, confirm your attendance by registering here: https://apo-opa.co/40KJQPE

Distributed by APO Group on behalf of CLG.

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Driving Africa’s Open Skies: Aircraft Manufacturers, Catalysts for Progress (By Henok Teferra Shawl)

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Henok Teferra Shawl

Significant progress has already been achieved; 37 African countries, representing over 80% of the continent’s aviation market, have joined the SAATM initiative

DAKAR, Senegal, January 31, 2025/APO Group/ — 

By Henok Teferra Shawl, Boeing Africa Managing Director (www.Boeing.com).

The liberalization of Africa’s air transport market, as envisioned through the Single African Air Transport Market (SAATM), is not just an aspirational goal — it is an economic necessity. A unified African sky, underpinned by the Joint Prioritized Action Plan (JPAP), promises to reduce travel costs for passengers, enhance connectivity, and catalyze economic growth and cultural exchange across the continent. The success of this initiative hinges on the active support and collaboration of governments, airlines and aircraft manufacturers such as Boeing.

The need for SAATM stems from longstanding challenges in Africa’s aviation sector: limited intra-African connectivity, high travel costs, fragmented regulations, constrained aircraft financing, and underdeveloped aviation infrastructure. These barriers have confined trade, tourism, economic and social integration for decades.

Aircraft manufacturers have a responsibility to help address these issues through policy engagement, partnerships, capacity building, and technology. We take pride in our role not just as fleet suppliers but critical enablers of the ecosystem and skills that Africa’s aviation industry needs to thrive.

Significant progress has already been achieved; 37 African countries, representing over 80% of the continent’s aviation market, have joined the SAATM initiative. Key regulatory frameworks are in place, including those for fair competition and consumer protection. Capacity-building programs for aviation professionals and improvements in safety standards are now aligned with international benchmarks.

Partnering with African airlines helps renew fleets with fuel-efficient and versatile aircraft designed to meet the continent’s unique operational requirements

However, to unlock SAATM’s full potential, sustained efforts are needed to address lingering challenges such as high operational costs, infrastructure gaps, and protectionist policies. Boeing is committed to contribute meaningfully in this regard.

Collaboration is a major lever. Aircraft manufacturers partner with governments and regional bodies to highlight the benefits of a liberalized air transport market. As an example, Boeing is an active participant in the African Aviation Industry Group. The group encourages more countries to commit to SAATM and work towards harmonizing regulatory standards, creating a more unified and efficient aviation ecosystem in Africa.

Air safety is one more area of collaboration across the continent. Aircraft manufacturers including Boeing support African countries in achieving the international standards set by the International Civil Aviation Organization (ICAO) and help enhance regional air safety working closely with airlines and organizations like African Airlines Association (AFRAA).

Fleet modernization is another key area where aircraft manufacturers can make a significant impact. Partnering with African airlines helps renew fleets with fuel-efficient and versatile aircraft designed to meet the continent’s unique operational requirements. Modernized fleets reduce operational costs and emissions and make air travel more competitive, accessible, and sustainable, a critical factor for the success of the Single African Air Transport Market (SAATM).

Capacity building is another essential contribution. Training programs for pilots, engineers, airline management, and other aviation professionals are vital to supporting the sector’s rapid growth and elevating passenger experience. Aircraft manufacturers, with their expertise and resources, are well-positioned to deliver world-class training and share best practices – and we are spearheading these efforts. Additionally, community engagement programs for African youth provide systemic improvement in science, technology, engineering, and maths (STEM) education and economic empowerment, directly feeding the talent pipeline. All these initiatives equip Africa’s aviation workforce with the skills needed to ensure a robust, safe and capable industry.

Finally, infrastructure enhancement is another important building block to SAATM. By providing counsel and data-driven analytics, aircraft manufacturers can assist in modernizing airports and air traffic management systems. This ensures the infrastructure is prepared to handle the anticipated increase in air traffic, enhancing safety and facilitating smoother, more efficient operations across the continent.

A fully realized SAATM will enable seamless travel and economic growth, fostering unity, and positioning Africa as a competitive player in the global aviation industry. The collaborative efforts of the African Union Commission and its implementing agency, the African Civil Aviation Commission, national governments, civil aviation authorities, the African Development Bank, African Airlines Association, airlines, and aircraft manufacturers through the Joint Prioritized Action Plan in support of SAATM are pivotal in achieving this vision.

Working together, we can ensure Africa’s aviation renaissance and the realization of the African Union vision, Agenda 2063: an integrated, prosperous and peaceful Africa, driven by its citizens and representing a dynamic force in the global arena.

Distributed by APO Group on behalf of Boeing.

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